Biochemistry

Fructose-6-phosphate Fructose- 1 ,6-diphosphate Fructose- 1 ,6-diphosphate is a typical product of glycolysis. Under the action of the enzyme aldolase, it is split into two trioses', phosphodioxyacetone and phosphoglycerol aldehyde. This division is called dichotomy, and glycolysis - the dichotomous cycle of carbohydrate metabolism. H,c — OPO,H, “ 1 32 c=o 1 HO — CH нс — OH H,C — OPO.H, HC=O Aldolase 1 1 нс — OH ---- *■ co + 1 нс — OH 1 H 2 C — OPO 3 H 2 H 2 c — OH H 2 C — OPO j H j Fructose- 1 ,6-diphosphate Dioxiacetonephosphate Glyccraldchydc-3-phosphate (acyclic form) (phosphoglycerol aldehyde) Under the action of the enzyme triosephosphateisomerase, the mutual transformation of triose is possible. With a ratio of 5% phosphoglyccrol aldehyde and 95% phosphodioxyacetone, mobile equilibrium is established. Phosphodioxiacetone is converted to glyceraldehyde-3-phosphate and all subsequent reactions proceed with two phosphoglycerol aldehyde molecules. In addition, it is restored in glyceraldehyde-3-phosphate, which is used to synthesize various lipids. Consequently, it is the /inA: between glycolysis and lipid metabolism. The formation of glyceraldehyde-3-phosphate completes the first, preparatory stage of glycolysis. The second stage, which is important, is the most difficult. It includes a redox reaction (glycolytic oxidation reduction), coupled with substrate phosphorylation, during which ATP is formed. 222