Biochemistry

R^OOH о О CH,OH II I R 2 -CCXj:H CH ’ OC-R, 2 II О 2,3- Diacylglycerol R 3 COOH О II CRjOC-R, CH,OC-R, 2 ц 'З o ■ Triacylglycerol R, — COCH 2 I CH 2 QH 1,2- Diacylglycerol R 3 COOH Н 2 О RjCOOH о CH,OH II I 2 R,-COCH 2 I CH 2 OH 2- Monoacylglycerol <-H 2 o ^* r 2 cooh сқон CHOH I CHjOH Glycerol (Glycerin) Figure 10.1 - Hydrolysis of triacylglycerols Lipases are of two types: one splits the ether bonds of triacylglycerols in positions 1 and 3, the other in position 2. The lipase contained in intestinal juice also participates in the breakdown of monoacylglycerols. Hydrolysis is the first phase of fat metabolism. It proceeds in steps, with the external ester bonds split first. Formed a-monoacylglycerols are absorbed by the intestine wall, then either go to the resynthesis of triacylglycerols in the intestine wall, or disintegrate under the action of nonspecific esterases. Fatty acids released from fissioned glycerols are poorly soluble in water and are absorbed by the intestinal villi only after interacting with bile acids with the formation of a pair of 191