Biochemistry

A gout disease develops with excessive consumption of meat products and enhanced biosynthesis of purine bases, including due to amino acids (aspartic, glutamic, glycine), as well as with difficulty removing uric acid from the body. In patients, the concentration of uric acid increases, 10-15 times higher than normal. Difficultly soluble uric acid is poorly excreted in the urine and is deposited in the form of salts in the area of small joints and under the skin. An inflammatory lesion occurs around the nodules, which leads to joint function failure and pain. Xanthine Oxidase Uricacid (human, monkey) Figure 9.1 - Uric acid formation Pyrimidine bases do not turn into purine, so they cannot be a source of uric acid. Unlike purines, deaminated pyrimidine bases are reduced, and then decomposed to carbon monoxide and ammonia. 181