Biochemistry

R Decarboxylase | r - ch - nh 2 -------------- ► ch 2 - nh 2 + co 2 I COOH The mechanism of the amino acid decarboxylation reaction in accordance with the general theory of pyridoxal catalysis is reduced to the formation of a pyridoxalphosphate-extract complex in the active center of the enzyme. In this way tryptamine will be formed from tryptophan, and serotonin from hydroxytryptophan. +CO, Histamine is formed from the histidine amino acid. 1 1 r-CH,-CH-COOH J t 1 N ---- r ! r CH,-CH, ' ! ■ nh 2 V nh 2 • -CO, \ 2 2 NH Гистидин Гистамин Histidine Histamine 168