Biochemistry

The elimination of the histamine excess occurs with the help of the enzyme histamine, which causes its deamination. Inactivation of histamine is carried out by methylation of its imidazole ring with the formation of 1,5-methylhistidine, as a result of acetylation (in reaction with acetyl-CoA) and binding to cellular proteins. ұ -Aminobutyric acid (GABA). It causes inhibition in the central nervous system. GABA has an inhibitory effect on the neurons dendrites in the brain and spinal cord. This acid has an important role in the energy metabolism of the brain. GABA is formed during the decarboxylation of glutamic acid. In turn, glutamic acid is formed from a-ketoglutaric acid, which is the most important substrate of the tricarboxylic acid cycle. COOH 1 co, У COOH _ 1 CH 2 1 л decarboxylase CH 2 [ CH 2 1 z CH 2 ~NH 2 CH 2 ch - nh 2 COOH ү -Aminobutyric acid Glutamine acid (GABA) Glycine is the second inhibitory mediator in the spinal cord and in the brain stem. It is formed from serine under the action of an enzyme containing a folic acid derivative - tetrahydro folate acid (THFA). COOH СН~ҺШ 2 +ТГФК CH 2 OH Serine Oxymethyl Transferase COOH I CH 2 I NH, Serene Glycine 281