Biochemistry

Biological role. Para-aminobenzoic acid is involved in the synthesis of folic acid in microorganisms, provides the growth of many plants. PAMBA affects the pigmentation and growth of hair and skin. There is evidence of vitamin Hi effects on the hormones of the thyroid gland and adrenal medulla. Deficiency of para-aminobenzoic acid. With a lack of vitamin H b hair growth slows down, their pigmentation is disturbed. Daily intake not established. For therapeutic purposes, para-aminobenzoic acid is used for infectious diseases, poisoning with preparations of arsenic, mercury, boric acid, and for sunbum at a dose of 2-4 g I day. Sources. PAMBA is found in rice bran, yeast, spinach, mushrooms, cattle liver, milk and other animal and vegetable products. Orotic acid (vitamin B 13 ). This compound is a pyrimidine derivative. It is able to enhance the growth of microorganisms and higher animals. Orotic acid has a positive effect on protein synthesis, improves liver function. Vitamin Bp is found in yeast, liver, milk. Daily intake has not been established. In newborns with blood diseases, chronic liver diseases, this drug is used at 1.5-3 g / day. Methylmethionine sulfonium (vitamin U). A CH 2 - CH 2 - CH - COOH group of American scientists led by R. Macrori was | able to identify natural vitamin U in 1954, isolated 'S-CH 3 NH 2 from cabbage juice in the form of crystalline | bromide, with synthesized methylmethionine CH 3 sulfonium bromide, which is an active form of Methylmethionine methionine. sulfonium Structure and physicochemical properties. Vitamin U is a white crystalline powder of a sweet-salty taste with a faint smell of cabbage, readily soluble in water, but not soluble in ethanol, glycerol, sulfuric ether. It is easily destroyed, at 100 °C, especially in neutral and alkaline environments, it is stable in an acidic environment. Biological role. Methylmethionine sulfonium is a macroergic compound, it is an active supplier of methyl groups for chemical processes associated with restoration of the mucous membranes of digestive organs. Daily intake not established. For prophylactic and therapeutic purposes (with peptic ulcer of the stomach and duodenum, chronic gastritis) sources of methionine sulfonium are used. Sources. Vitamin U is found in the juices of raw vegetables and fruits (cabbage, parsley, tomatoes, celery). Pangamic acid (vitamin B I5 ). This vitamin is contained in the seeds of plants, (from the Greek. Pan - everything and gamu - seed). It was synthesized in 1961.