Biochemistry

Riboflavin deficiency. The lack of vitamin B 2 in the body leads to a weakening of the tissue respiration processes, which contributes to growth retardation, increased decomposition of tissue proteins. With prolonged nutrition of plant products (especially refined), an excretion of vitamin B 2 from the body is enhanced. Ariboflavinosis - riboflavin deficiency in the body, which is manifested by inflammation of the face skin and oral mucosa can develop with diseases of the gastrointestinal tract or with an increased need for this vitamin (pregnancy, infectious diseases, etc.). Deep cracks appear in the comers of the mouth, the tongue becomes inflamed, and the tongue papillae atrophy. Face skin becomes glossy and then peels off. Daily intake of vitamin B 2 is 1.5-3 mg. It increases in people whose work causes profuse sweating, is associated with high visual stress, a possible effect on the body of toxic agents that affect the liver, blood-forming organs. The need for vitamin В 2 increases during pregnancy and lactation, as well as for various diseases. Sources. Valuable sources of vitamin B 2 are milk, daily products, as well as eggs, meat, liver, and kidneys. In plant foods, riboflavin is mainly found in legumes, buckwheat. Pyridoxine (vitamin B 6 , adermin). It was discovered as an independent indispensable food factor in 1934 by P. Gyorgy after the water-soluble vitamins B! , B 2 and PP known by then did not eliminate the special form of limb dermatitis in rats called acrodenia. Vitamin B 6 was first isolated in 1938 from yeast and liver, and then was synthesized chemically. CH 2 OH H 3 crV N <^ Pyridoxol (pyridoxine) /О C< H ch 2 nh 2 но-ү-^ч^снгон Pyridoxal Pyrldoxamine Structure and physicochemical properties. Pyridoxine is a derivative of 3- hydroxypyridine. According to the recommendations of the International Commission on the Nomenclature of Biological Chemistry ( 1970), the term “ pyridoxine ” combines three derivatives of 3 -hydroxypyridine with vitamin activity: pyridoxine (pyridoxol), pyridoxal and pyridoxamine. Pyridoxine (pyridoxol) - 2-methyl-3-hydroxy-4,5-dioximethylpyridine, is an alcohol. When the oxymethyl group is oxidized (in a known position) to the 250