Biochemistry

(Glycolysis) (P-oxidation of fatty acids) #8 #2 •OOC — CH Fumarate Malate Krebs cycle Tricarboxylic acid (TCA) cycle Citric acid cycle HjC — coo- I h — c — coo- I HQ — С — COO- H Isocitrate CO ? FADH #4 #5 NADH. H+ Succinate dehydrogenase Succinyl-CoA synthetase NAD+ Isocitrate dehydrogenase a-ketoglutarate dehydrogenase --------- NAD+ #3 Succinate CoASH Succinyl-CoA «-ketoglutarate CoASH Figure 8.2 - A modern view of urea synthesis The work of X. A. Krebs and other researchers showed the participation in this process of substances and enzymes that catalyze urea synthesis reactions. English biochemist Hans Adolf Krebs made a great contribution to the modern theory of urea synthesis. He established that this process has cyclical nature and indicated 173